Dean, Angela; Lewis, Susan (Eds.)

Screening
Methods for Experimentation in Industry, Drug Discovery, and Genetics

2006, XIII, 326 p. 52 illus., Hardcover
ISBN: 0-387-28013-8

About this book

The process of discovery in science and technology may require investigation of a large number of features, such as factors, genes or molecules. In Screening, designed experiments and statistical analyses of the resulting data sets are used to identify efficiently the few features that determine key properties of the system under study.

This book brings together accounts by leading international experts that are essential reading for those working in fields such as industrial quality improvement, engineering research and development, genetic and medical screening, drug discovery, and computer simulation of manufacturing systems or economic models. Our aim is to promote cross-fertilization of ideas and methods through detailed explanations, a variety of examples and extensive references.

Topics cover both physical and computer simulated experiments. They include screening methods for detecting factors that affect the value of a response or its variability, and for choosing between various different response models. Screening for disease in blood samples, for genes linked to a disease and for new compounds in the search for effective drugs are also described. Statistical techniques include Bayesian and frequentist methods of data analysis, algorithmic methods for both the design and analysis of experiments, and the construction of fractional factorial designs and orthogonal arrays.

The material is accessible to graduate and research statisticians, and to engineers and chemists with a working knowledge of statistical ideas and techniques. It will be of interest to practitioners and researchers who wish to learn about useful methodologies from within their own area as well as methodologies that can be translated from one area to another.

Table of contents

An Overview of Screening Experiments in Industry, D.C. Montgomery, C.L. Jennings.- Screening Experiments for Dispersion Effects, D. Bursztyn, D.M. Steinberg.- Pooling experiments for blood screening and drug discovery, J. Hughes-Oliver.- Pharmaceutical drug discovery: hunting the blockbuster drug, D. Cummins.- Design and Analysis of Screening Experiments with Microarrays, P. Sebastiani, J. Jeneralczuk, M.F. Ramoni.- Multiple Comparisons in Screening for Differential Gene Expressions from Microarray Data, J.C. Hsu, J.Y. Chang, Tao Wang.- Projection Properties of Factorial Designs for Factor Screening, Ching-Shui Cheng.- Factor screening via supersaturated designs, S. Gilmour.- An Overview of Group Factor Screening, M.D. Morris.- Screening designs for model selection, W. Li.- Prior distributions for Bayesian analysis of screening experiments, H. Chipman.- Adaptive Analysis of Orthogonal Saturated Designs, D.T. Voss, Weizhen Wang.- Finding the important factors in large discrete-event simulation, J.P.C. Kleijnen, B. Bettonvil, F. Persson.- Screening the Input Variables to a Computer Model Via Analysis of Variance and Visualization, M. Schonlau, W.J. Welch.

Keller, Agathe

Expounding the Mathematical Seed

Series: Science Networks. Historical Studies , Vol. 30/31
2006,
ISBN: 3-7643-7299-0

About this book

This set of books presents an english translation of a 7th century sanskrit commentary written by an astronomer called Bhaaskara. There are two volumes:

Volume I contains an introduction and the literal translation. The introduction aims at providing a general background for the translation and is divided in three sections: The first locates Bhaaskara's text, the second looks at its mathematical contents and the third section analyzes the relations of the commentary and the translation. Subjects treated range from computing the volume of an equilateral tetrahedron to the interest on a loaned capital, from computations on series to an elaborate process to solve a Diophantine equation.

Volume II contains a commentary for each verse which discusses the linguistic and mathematical matter exposed by the commentator. This volume also contains glossaries and the bibliography. The two volumes should be read simultaneously.

Written for:
Postgraduates and researchers in history of science, people interested in history of Indian mathematics

Cercignani, Carlo

Slow Rarefied Flows
Theory and Application to Micro-Electro-Mechanical Systems

Series: Progress in Mathematical Physics , Vol. 41
2006, XI, 166 p., Hardcover
ISBN: 3-7643-7534-5

About this book

The book presents the present status of the mathematical tools used to deal with problems related to slow rarefied flows, with particular attention to basic concepts and problems which arise in the study of micro- and nanomachines. The mathematical theory of slow flows is presented in a practically complete fashion and provides a rigorous justification for the use of the linearized Boltzmann equation, which avoids costly simulations based on Monte Carlo methods. The book surveys the theorems on validity and existence, with particular concern for flows close to equilibria, and discusses recent applications of rarefied lubrication theory to micro-electro-mechanical systems (MEMS).

Written for:

Graduates, postgraduates and researchers interested in the mathematical treatment of flows; mathematical physicists

Table of contents


Zhong, Qing-Chang

Robust Control of Time-delay Systems

2006, XXII, 231 p. 79 illus., Hardcover
ISBN: 1-84628-264-0

About this book

Systems with delays appear frequently in engineering; typical examples of time-delay systems are communication networks, chemical processes and tele-operation systems. The presence of delays makes system analysis and control design much more complicated. During the last decade, we have witnessed significant developments in robust control of time-delay systems. Robust Control of Time-delay Systems presents a systematic and comprehensive treatment for robust (H-infinity) control of such systems in the frequency domain. The emphasis is on systems with a single input or output delay, although the delay-free part of the plant can be multi-input-multi-output, in which case the delays in different channels should be the same.

This synthesis of the authorfs recent work covers the whole range of robust control of time-delay systems: from controller parameterization and design to controller implementation; from the Nehari and one-block problems to the four-block problem; from theoretical developments to practical issues. The major tools used in this book are similarity transformation, the chain-scattering approach and J-spectral factorization. The idea is, in the words of Albert Einstein, to "make everything as simple as possible, but not simpler". A website associated with the book is a source of MATLABR and SimulinkR material which will assist with simulation and modelling of the material in the text.

Robust Control of Time-delay Systems is self-contained and will interest control theorists, researchers and mathematicians working with time-delay systems and engineers looking to design commercial controllers or to use them in plants or communication systems with time delays. Its methodical approach will also be of value to graduates studying either general robust control theory or its particular applications in time-delay systems.

Table of contents

Introduction.- Part I: Controller Design.- Classical Control of Time-delay Systems.- Preliminaries.- J-spectral Factorization of Regular Para-Hermitian Transfer Matrices.- The Delay-type Nehari Problem.- An Extended Nehari Problem.- The Standard H-Infinity Problem.- A Transformed Standard H-Infinity Problem.- 2DoF Controller Parameterization.- Unified Smith Predictor.- Part II: Controller Implementation.- Discrete-delay Implementation of Distributed Delay in Control Laws.- Rational Implementation Inspired from the delta-operator.- Rational Implementation Bases on the Bilinear Transformation.